Stanislav Grof, . Jim Binnion. A drug that depresses the central nervous system is. D) colon cancer. However, several cross-sectional studies have shown that repeated long-term cannabis use is associated with smaller grey matter volumes in the hippocampus, amygdala, medial temporal . Pleasure should bring intimacy and joy, and not worry or concern whether the ingredients are safe for long term use. How to Stop Drinking Alcohol A Simple Path from Alcohol Misery to Alcohol Mastery. Individuals using meth are at higher risk of hepatitis C and HIV due to sharing needles and other drug equipment. Chronic use has been shown to cause organ problems including pancreatitis and liver damage. However, several cross-sectional studies have shown that repeated long-term cannabis use is associated with smaller grey matter volumes in the hippocampus , amygdala , medial temporal cortex , and prefrontal cortex , with increased grey matter volume in . The first amfeta-mine-psychosis occurred in 1938. 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