Statin Dose Equivalency Chart. Primary prevention - Primary LDL-C ≥190 mg/dL a. Interactions With Statins Table. PDF Statins and Triglycerides - LipidCenter Quick reference drug comparison charts. Rockville (MD): Agency for Healthcare Research and Quality (US); 2016 Nov. (Evidence Syntheses, No. The safety of rosuvastatin in comparison with other statins in over 25,000 statin users in the Saskatchewan Health Databases. 20 Several treatment groups require calculation of an . PDF Lipid Modification for Non-familial Hypercholesterolaemia ... Table 1, Statin Dosing and ACC/AHA Classification of Intensity - Statin Use for the Prevention of Cardiovascular Disease in Adults Your browsing activity is empty. Statin Dose Intensity and Equivalency Chart* Statin Intensity %LDL-C Reduction HMG-CoA Reductase Inhibitor Rosuvastatin Atorvastatin Pitavastatin Simvastatin Lovastatin Pravastatin Fluvastatin High-Intensity (lowers LDL-C ≥ 50%) 63 40 mg ($196) 62 61 60 80mg ($9 gen, $ 236. br) 59 58 56 20 mg 54 ($196) 52 Low-Density Lipoprotein Cholesterol-targeting Statin ... Age >75 y or safety concerns: Moderate-intensity statin I A 2. For more information about the inputs and calculations used in this app, see "Terms and Concepts" in the Resources tab below. Table 1, Statin Dosing and ACC/AHA Classification of Intensity. ASK DIS: Statins : Administration Time & Equivalence Considerations in the Approach to Appropriate Statin Selection Pharmainetics Of Statins Table. During a mean follow-up of 492 days, there was a graded association between intensity of statin therapy and mortality, with 1-year mortality rates of 4.0% (5103 of 126 139) for those receiving high-intensity statin therapy, 4.8% (9703 of 200 709) for those receiving moderate-intensity statin therapy, 5.7% (1632 of 28 765) for those receiving . Statins are the drugs of choice for decreasing LDL-C and are used for the prevention and management of ASCVD. Moderate-intensity, aiming at a 30% to 49% reduction in LDL-C. Statin therapy is divided into 3 categories of intensity: High-intensity, aiming for at least a 50% reduction in LDL-C. 50%) 63 40 mg ($196) 62 61 60 S. trength . To discuss conversion to the Preferred Drug or to request authorization for a Non-Preferred To date, some statin-related studies have focused on the comparison between statin combination therapies with statin monotherapies [8, 9], and others (mainly network meta-analyses) have focused on the comparative tolerability or comparative effects among different statins [10, 11]; however, the outcome indicators were mainly the occurrence and . By inhibiting this enzyme, cholesterol and LDL-cholesterol production is decreased. associated with higher-intensity statin use were determined by multivariate analysis. Statins (also called HMG-CoA reductase inhibitors) block an enzyme called HMG-CoA reductase that is involved in the synthesis of mevalonate, a precursor to sterols such as cholesterol. High-intensity statin therapy Moderate-intensity statin therapy Prescription Rosuvastatin 20-40 mg Simvastatin 80 mg Ezetimbe-simvastatin 80 mg Sitagliptin-simvastatin 20-40 mg Pravastatin 40—80 mg Lovastatln 40 mg Niacin-lovastatin 40 mg Fluvastatin XL 80 mg Fluvastatin 40 mg bid Pitavastatin 2—4 mg Atorvastatln 40—80 mg - When used together, low- or moderate-intensity statins are best to reduce AE risk. NICE have produced a series of patient decision aids (PDAs) to enable patients to assess the risks and benefits of commencing statins. Written by Kupis on March 19, 2018 in Chart. ** 10-year risk for ASCVD is categorized as: Low-risk (<5%) Borderline risk (5% to 7.4%) Intermediate risk (7.5% to 19.9%) High risk (≥20%) Indicates a field required to calculate current 10-year ASCVD risk for patients age 40-79 or Lifetime risk for patients age . Comparison Chart . The appropriate intensity of statin therapy should be initiated or continued: 1. Low-dose statin + ezetimibe can reduce low-density lipoprotein cholesterol (LDL-C) almost to the level of high-intensity statins. Guidelines recommend that subjects with high and very high ASCVD risk should be treated with high-intensity statins or a combination of . (Am J Cardiol 2003;93:152- 160). statins, statin therapy should be maximized first(to high intensity) (high-level evidence). (5) In a review of Get with the Guideline data, only 1 in 5 patients with a prior TIA/stroke had LDL levels <70 mg/dL — Ten-year ASCVD risk — which includes both coronary events and stroke — is . The factors included in the models were age, sex, statin type and intensity, statin duration and a range of comorbidities, such as stroke, hypertension, smoking status, dyslipidaemia and diabetes. Start a moderate-intensity and increase the dose to high-intensity. Rosuvastatin 20-40 mg daily. We previously used this method to compare individual statins in terms of their cholesterol-lowering effects, as well as their effects on deaths, coronary events, and cerebrovascular events. Similarly, a meta-analysis of 13 randomized statin trials with 91,140 participants showed an odds ratio of 1.09 for a new diagnosis of diabetes, so that (on average) treatment of 255 patients with . Similar results were observed for non-high-density lipoprotein cholesterol (non-HDL-C). Statin ociated myopathy cholesterol lowering s endotext ociation of statin therapy with statins in the primary prevention of. The mechanism of action is the same as how they lower LDL-C. Depletion of hepatic cholesterol pools by statin-induced inhibition of HMGCoA The Food and Drug Administration (FDA) offers advice on the risks related to taking statins: Controlling Cholesterol with Statins. Cost per 28 days. Methods/design. Examples: Atorvastatin 40-80 mg daily. • We suggest that the monitoring of repeat lipid levels after a patient begins lipid-lowering therapy is not required (low-level evidence). In comparison, most previous studies tested low (fluvastatin 40 mg; pravastatin 20 mg; simvastatin 10 mg) or moderate (simvastatin 20-40 mg; lovastatin 40 mg) intensity statins and only two studies 21, 44 used high intensity statin (both with lovastatin 80 mg). — With few exceptions, use of lipid-modifying drugs other than statins is discouraged. One: prescription claim for a : moderate to high intensity statin : One. Measure total cholesterol, HDL- C and non -HDL-C in all people who have been started on a high intensity statin treatment at 3 months and aim for greater than 40% reduction in nonHDL- -C. 9. Cholesterol is a waxy, fat-like substance that is naturally present in cell walls or membranes everywhere in the body. Clinical ASCVD* a. Primary prevention - Primary LDL-C ≥190 mg/dL a. If 10-year CVD risk is ≥ 20%, it may be reasonable to add ezetimibe to maximally-tolerated statins in order to . Access to the entire archive. Intensity of Statin Therapy High Moderate Low LDL-C ≥50% LDL-C 30 to <50% LDL-C <30% Atorva 40-80 mg Rosuva 20-40 mg Atorva 10 mg Rosuva 10 mg Simva 20-40 mg Pravas 40 mg Lova 40 mg Fluva XL 80 mg Fluva 40 mg bid Pitava 2-4 mg Simva 10 mg Prava 10-20 mg Lova 20 mg Fluva 20-40 mg Pitava 1 mg Statins in bold were evaluated in randomized . Diabetes (SUPD) 1-weight . Clinical ASCVD* a. - Gemfibrozil should not be used with a statin. Lovastatin 40-80 mg The Prediction of Muscular Risk in Observational Conditions (PRIMO) study reported a myopathy rate of 10.5% of patients (832 out of 7,924) who were receiving high-dose statin therapy (fluvastatin 80 mg; atorvastatin 40 or 80 mg; pravastatin 40 mg; or simvastatin 40 or 80 mg) with a median onset of . Low-intensity statins' LDL (low-density lipoprotein) lowering is less than 30%, moderate-intensity statins' LDL lowering is between 30-50%, while high-intensity statins are expected to reduce LDL at 50% or higher [5]. High-intensity statin should be considered. 80% of the year . Prevalence of ASCVD was 12.3%. Low-Density Lipoprotein Cholesterol-targeting Statin Therapy Versus the Intensity-based Statin Therapy in Patients With Coronary Artery Disease: a Randomized Comparison Trial (LODESTAR) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Moderate-intensity statin therapies include atorvastatin (10-20 mg), rosuvastatin (5-10 mg), simvastatin (20-40 mg), pravastatin (40-80 mg), and several others. For the purpose of this guideline, statins are grouped into 3 different intensity categories according to the percentage reduction in low-density lipoprotein cholesterol: a 20% to 30% reduction is low intensity. Table 3A Comparison of peripheral blood plasma concentrations of different statins in individuals with homozygous (OATP1B1) 521CC (dysfunctional) compared with those with fully functional homozygous (OATP1B1) 521 TT (fold AUC changes are based on group mean AUC 0-N)* Statin AUC change Simvastatin acid 3.21-fold [ (1221%) 44 - 46 Our findings show that there are statistically detectable differences between individual statins in terms of their tolerability, hepatic . prescription claim for a : statin . Prescription claims for a . No ASCVD and no ASCVD risk factors: Moderate-intensity statin; No ASCVD with ASCVD risk factors: At the least, moderate-intensity statin. statin. Lipid profile does not have to be a fasting one. A high-intensity statin, defined as the dose at which a reduction in LDL-cholesterol of greater than 40% is achieved, is recommended as first-line therapy in all patients with familial hypercholesterolaemia. Statin dosing is classified into low-intensity, moderate-intensity, and high intensity. Other high-intensity statins are rosuvastatin 10-40 mg daily and simvastatin 80 mg daily. • Measure total, HDL and non-HDL cholesterol 3 months following initiation of high intensity statin. S. trength (July 2013 Drug Tariff) % reduction in LDL cholesterol. Rosuvastatin and high-dose simvastatin. Whats people lookup in this blog: High Intensity Statin Table; High Intensity Statin Chart; Moderate High Intensity Statin Chart Statin and . Statin Effectiveness And Cost Comparison Recommend Generics *For all statins, check liver function tests at baseline and when clinically indicated. Age ≤75 y and no safety concerns: High-intensity statin I A b. Statin intensity was defined on the basis of the daily dose at the time of enrollment using the previously defined 2013 ACC/AHA cholesterol guideline schema. 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